Supplemental diet d and incident fractures in midlife and older adults

 Supplemental nutrition d and incident fractures in midlife and older adults

meryl s. Leboff, m. D., sharon h. Chou, m. D., kristin a. Ratliff, b. A., nancy r. Cook dinner, sc. D., bharti khurana, m. D., eunjung kim, m. S., peggy m. Cawthon, ph. D., m. P. H., douglas c. Bauer, m. D., dennis black, ph. D., j. Chris gallagher, m. D., i-min lee, m. B., b. S., sc. D., julie e. Buring, sc. D., et al. Abstract

background

diet d dietary supplements are extensively endorsed for bone health inside the general populace, but facts on whether or not they prevent fractures had been inconsistent. Techniques

in an ancillary observe of the nutrition d and omega-3 trial (essential), we examined whether supplemental vitamin d3 could result in a decrease danger of fractures than placebo. Essential turned into a two-by using-two factorial, randomized, controlled trial that investigated whether supplemental nutrition d3 (2000 iu in step with day), n−3 fatty acids (1 g according to day), or both could prevent cancer and cardiovascular sickness in men 50 years of age or older and ladies fifty five years of age or older within the u. S.. Members have been not recruited on the premise of nutrition d deficiency, low bone mass, or osteoporosis. Incident fractures have been pronounced by contributors on annual questionnaires and adjudicated by means of centralized scientific-document evaluation. The number one cease points have been incident overall, nonvertebral, and hip fractures. Proportional-hazards fashions have been used to estimate the treatment impact in goal-to-treat analyses. Outcomes

amongst 25,871 members (50. 6% girls [13,085 of 25,871] and 20. 2% black [5106 of 25,304]), we showed 1991 incident fractures in 1551 members over a median follow-up of 5. Three years. Supplemental vitamin d3, compared with placebo, did no longer have a large effect on total fractures (which occurred in 769 of 12,927 individuals inside the diet d organization and in 782 of 12,944 participants in the placebo institution; danger ratio, zero. 98; 95% confidence c language [ci], 0. 89 to at least one. 08; p=0. 70), nonvertebral fractures (risk ratio, zero. Ninety seven; ninety five% ci, 0. 87 to 1. 07; p=0. 50), or hip fractures (hazard ratio, 1. 01; ninety five% ci, 0. 70 to 1. 47; p=zero. 96). There was no amendment of the treatment impact in keeping with baseline characteristics, which includes age, intercourse, race or ethnic institution, frame-mass index, or serum 25-hydroxyvitamin d degrees. There were no massive among-institution variations in unfavorable occasions as assessed within the discern trial. Conclusions

nutrition d3 supplementation did now not bring about a significantly lower danger of fractures than placebo amongst generally healthful midlife and older adults who have been no longer selected for nutrition d deficiency, low bone mass, or osteoporosis. (funded via the countrywide institute of arthritis and musculoskeletal and skin diseases; important clinicaltrials. Gov number, nct01704859. Opens in new tab.)

virtual item thumbnail

quick take video summary

nutrition d and fracture danger among adults

 01:forty seven

continue studying this text

pick out an alternative underneath:

create your account to get 2 loose subscriber-best articles every month. Get unfastened get right of entry to now

subscribe for full get right of entry to

have already got an account? Sign up

print subscriber? Set off your online access. Are you a member of an group consisting of a university or clinic? Analyze greater about institutional get right of entry to

supported by using offers (r01 ar060574, r01 ar070854, and r01 ar059775, to dr. Leboff) from the countrywide institute of arthritis and musculoskeletal and skin illnesses. The critical parent trial is supported by means of grants (u01 ca138962, r01 ca138962, and r01at011729, to drs. Manson and buring) from the national most cancers institute, the countrywide coronary heart, lung, and blood institute, the office of nutritional supplements, the countrywide institute of neurological problems and stroke, and the country wide middle for complementary and integrative fitness. Disclosure bureaucracy provided by using the authors are available with the whole text of this text at nejm. Org. A data sharing statement provided by way of the authors is to be had with the total text of this article at nejm. Org. Creator affiliations

from the department of endocrinology, diabetes, and high blood pressure (m. S. L., s. H. C., k. A. R.), the division of preventive medicinal drug (n. R. C., e. K., i.-m. L., j. E. B., j. E. M.), and the department of radiology (b. K.), brigham and ladies’s hospital, harvard clinical college (m. S. L., s. H. C., n. R. C., b. Okay., i.-m. L., j. E. B., j. E. M.), and the branch of epidemiology, harvard t. H. Chan faculty of public health (n. R. C., i.-m. L., j. E. B., j. E. M.) — all in boston; california pacific medical middle studies institute (p. M. C.), and the departments of epidemiology and biostatistics (p. M. C., d. C. B., d. B.) and remedy (d. C. B.), university of california, san francisco — each in san francisco; and the branch of endocrinology, creighton college faculty of medicine, omaha, ne (j. C. G.). Dr. Leboff may be contacted at mleboff@bwh. Harvard. Edu or at the department of endocrinology, diabetes, and hypertension, brigham and ladies’s sanatorium, 221 longwood ave., boston, ma 02115. July 28, 2022

n engl j med 2022; 387:299-309

doi: 10. 1056/nejmoa2202106

print subscriber? Prompt your on-line get entry to. Related articles

editorialjul 28, 2022

important findings — a decisive verdict on vitamin d supplementation

s. R. Cummings and c. Rosen

returned to top